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Biocompatible polymer nanocapsules with quantum dots, method of manufacturing them and their application
专利权人:
POLITECHNIKA WROCŁAWSKA
发明人:
BAZYLIŃSKA URSZULA,BAZYLIŃSKA URSZULA,DROZDEK SŁAWOMIR,DROZDEK SŁAWOMIR,NYK MARCIN,NYK MARCIN,KULBACKA JULITA,KULBACKA JULITA,SAMOĆ MAREK,SAMOĆ MAREK,WILK KAZIMIERA ANNA,WILK KAZIMIERA ANNA
申请号:
PL40766414
公开号:
PL224603B1
申请日:
2014.03.26
申请国别(地区):
PL
年份:
2017
代理人:
摘要:
the invention discloses biokompatybilne nanokapsu\u0142y with quantum dots, which outer layer is in the form of a non-ionic surfactant polietoksylowanego castor oil.in between the outer shell and an oil core loaded with quantum dots as tracers cdse - zns type \"core - shell\" is a layer of polymer triblokowego consisting of 20 units of polyoxyethylene (peo), followed by 70 units polioksyp ropylenu (c.a.p.), and then again with 20 units of polyoxyethylene (peo).the invention also relates method of production biokompatybilnych nanokapsu\u0142 with quantum dots, which is that in the first stage a 4.6 ml dichloromethane soluble 150 g of polymer triblokowego consisting of 20 units of polyoxyethylene (peo), followed by 70 j ednostek polioksypropylenu (c.a.p.), and then again with 20 units of polyoxyethylene (peo), 12.5 - 50 mg oil and 1 - 3 mg of quantum dots cdse - zns type \"core - shell\" dissolved in hexane, and so prepared organic phase is mixed for 30 minutes at a temperature of 25 degrees celsius.in the second stage, the whole is subjected to the action of ultrasound by 90 seconds and the excess solvent vaporized under reduced pressure at a temperature of 100 degrees and in the third stage, 5 ml of aqueous phase solution polietoksylowanego castor oil, at a concentration of 50 mg \/ ml in pla to evaporated mixtureall mixed at a temperature of 105 for 2 hours and so obtained nanokapsu\u0142 suspension polymer loaded quantum dots cdse \/ zns is subjected to the action of ultrasound by 3 - 8 minutes and mixed by another 12 hours at room temperature.then in the third stage loaded polymeric nanokapsu\u0142y undergo process nanofiltracji by membranes with polieterosulfonu pore diameter equal to 200 nm.the invention also includes the use of quantum dots biokompatybilnych nanokapsu\u0142 having an outer layer, which is a non-ionic surfactant in the form of polietoksylowanego castor oil.in between the outer shell and an oil core loaded with quantum dots as tracers cdse - zns
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