Disclosed herein are phosphorothioate nucleotide analogs, methods of synthesizing phosphorothioate nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with the phosphorothioate nucleotide analogs.Cette invention concerne des analogues nucléotidiques phosphorothioates, des méthodes de synthèse de ces analogues nucléotidiques phosphorothioates et des méthodes de traitement de maladies et/ou daffections, notamment les infections virales, le cancer et/ou les parasitoses, à laide de ces analogues nucléotidiques phosphorothioates.