The present invention relates to compounds of the general formula (I), wherein the meaning of A is CH or nitrogen atom； the meaning of R is hydrogen or halogen atom or C1-C6 straight or branched chain alkyl group； the meaning of R1 is hydrogen or halogen atom or C1-C6 straight or branched chain alkyl group, or C1-C6 straight or branched chain alkoxy group, or mono- or polyhalogenated C1-C6 straight or branched chain haloalkyl group； the meaning of R2 is hydrogen or halogen atom or C1-C6 straight or branched chain alkyl group, or C1-C6 straight or branched chain alkoxy group or mono- or polyhalogenated C1-C4 straight or branched chain haloalkyl group； the meaning of R3 is hydrogen or C1-C6 straight or branched chain alkyl group, optionally substituted with C3-C6 cycloalkyl group, or mono- or polyhalogenated C1-C6 straight or branched chain haloalkyl group； or C3-C6 cycloalkyl group, or C1-C6 straight or branched chain alkanoyl group and/or salts, and/or geometric isomers, and/or stereoisomers, and/or diastereomers, and/or hydrates, and/or solvates, and/or polymorph modifications thereof. The present invention relates to new substituted diazepino-indole derivatives of the general formula (I), and to pharmaceutically acceptable salts thereof, as well as to pharmaceutical compositions comprising such compounds, to new intermediate thereof, as well as to the use of such compounds in treatment or prevention of disorders associated with melanin-concentrating hormone receptor 1 activity.本發明關於通式(I)化合物，其中A之意義為CH或氮原子；R之意義為氫或鹵素原子或C1-C6直鏈或支鏈烷基；R1之意義為氫或鹵素原子，或C1-C6直鏈或支鏈烷基，或C1-C6直鏈或支鏈烷氧基，或經單-或多鹵化之C1-C6直鏈或支鏈鹵烷基；R2之意義為氫或鹵素原子，或C1-C6直鏈或支鏈烷基，或C1-C6直鏈或支鏈烷氧基，或經單-或多鹵化之C1-C4直鏈或支鏈鹵烷基；R3之意義為氫，或隨意地經C3-C6環烷基取代之C1-C6直鏈或支鏈烷基，或經單-或多鹵化之C1-C6直鏈或支鏈鹵烷基；或C3-C6環烷基，或C1-C6直鏈或支鏈烷醯基，及/或其鹽、及/或其幾何異構物、及/或其立體異構物、及/或其非鏡像異構物、及/或其水合物、及/或其溶劑合物、及/或其多形修飾物。本發明關於新的通式(I)的經取代之二氮呯并吲哚衍生物及其醫藥上可接受之鹽、以及包含此等化合物之醫藥組成物、新的其中間物、以及此等化合物在治療或預防與黑色素濃縮激素受體1活性相關聯的病症之用途。
