This disclosure includes an immunogenic composition containing (a) a glycan conjugate including a carrier and one or more glycans, wherein each of the one or more glycans is conjugated with the carrier through a linker, and optionally (b) an adjuvant. The one or more glycan is each a Globo H derivative.本揭示內容包含一種免疫組合物,其係包含(a)一包含載體及一或多聚醣的聚醣共軛物,其中一或多聚醣中的每一個聚醣皆係經由連結子與載體形成共軛,以及非必要性的(b)一佐劑。該一或多聚醣是一Globo H衍生物。