A system or method includes an infusion apparatus controllable to provide a fluid flow from a replaceable fluid dispenser at a set flow rate. The infusion apparatus may be commanded to operate on a replacement fluid dispenser to provide one or more boluses of the plurality of boluses into an infusion line. If the infusion apparatus is not being prevented (e.g., by system back pressure or frictional forces) from delivering the one or more boluses then the infusion apparatus may be controlled to deliver a plurality of boluses at a set flow rate. If the infusion apparatus is being prevented from delivering the one or more boluses then the infusion apparatus may be controlled to pressure prime the replacement fluid dispenser by accelerating one or more commands to the infusion apparatus to deliver one or more boluses into the infusion line.
