Christine E. Brotherton-Pleiss,Francisco Javier Lopez-Tapia,Yan Lou
申请号：
US13706399
公开号：
US08742098B2
申请日:
2012.12.06
申请国别(地区):
US
年份:
2014
代理人:
摘要：
This application discloses compounds according to generic Formula I:wherein the variables are defined as described herein, and which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation, such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
