INDUSTRY ACADEMIC COOPERATION FOUNDATION; HALLYM UNIVERSITY
发明人:
PARK, CHUM HUMKR,박찬흠,LEE, OK JOOKR,이옥주,JU, HYUNG WOOKR,주형우,LEE, JUNG MINKR,이정민,KIM, JUNG HOKR,김정호,MOON, BO MIKR,문보미,PARK, HYUN JUNGKR,박현정,KIM, DONG WOOKKR,김동욱,LEE, MIN CHAEKR,이민채,KIM, SOO HYEONKR,김수현
申请号：
KR1020140125486
公开号：
KR1020160034557A
申请日:
2014.09.22
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to a bone inductive artificial bone support including a silk protein, and a method of manufacturing the same. In addition, the present invention relates to an artificial bone support physically combined with a PLGA support by mixing a silk protein (or silk fibroin) extracted from cocoon or fibroin with hydroxyapatite nanoparticles. It is tried to replace a damaged bone tissue with a normal bone tissue or to regenerate a damaged bone tissue, and interests in the development of a bone tissue for implantation is increased. A method of implanting a bone of another person or an animal, or a method of implanting a tissue of a patient has been widely used, but the immunological rejection occurs or a damaged area is large by implanting a tissue of others. Therefore, a case in which a material which can be used in a body of a patient is not sufficient, might occur. Accordingly, the development of a safe artificial bone which can be easily supplied and manufactured in various forms, is required. To solve the problem of the present invention, advantages of mass-productivity, biodegradability, a bone regeneration function, excellent biocompatibility, and having no biological hazards of silk fibroin, and advantages of safety, and mechanical strength biodegradability of PLGA (polylactic-glycolic acid) are mixed. Therefore, provided is the artificial bone having a structure of two materials, morphologically, a physically mixed hybrid support structure in which a PLGA support surrounds a silk fibroin support, and having advantages of the two materials.COPYRIGHT KIPO 2016본 발명은 실크단백질을 포함한 골 유도 인공 뼈 지지체 및 그 제조 방법에 관한 것으로, 누에고치 또는 견섬유에서 추출한 실크단백질(또는 실크피브로인)에 하이드록시아파타이트 나노입자와 혼합하여 PLGA 지지체와 물리적으로 결합한 인공 뼈 지지체에 대한 것이다.현대에 이르러 손상된 골조직을 정상적인 골조직으로 대체하거나 재생시키려는 시도를 하고 있으며, 이에 따라 체내 이식을 위한 골조직의 개발에 관심이 증대 되고 있다. 하지만, 타인이나 동물의 뼈를 이식하는 방법이나 환자 자신의 조직을 이식하는 방법을 많이 사용하고 있지만 타의 조직을 이식함으로써 면역학적 거부반응이 발생되거나 손상부위가 커서 환자 몸에서 사용할 수 있는 재료가 충분하지 않은 경우가 생기기도 한다. 따라서 수급이 용이하고
