Method for the treatment or prevention of a cardiovascular event in a subject with atherosclerotic vascular disease, the use of a compound of formula (I),A derivative of colchicine known and \/ or a salt of the same, composition for the prevention or treatment of a cardiovascular event in a subject with atherosclerotic vascular disease.Method and system for reducing or preventing the inflammation induced by cholesterol crystal within the atherosclerotic plaque in a subject.The scheme for the treatment or prevention of a cardiovascular event in an individual
A method for the treatment or prevention of a cardiovascular event in a subject with atherosclerotic vascular disease comprising the step of: b) administering a therapeutically effective amount of a compound of formula (I), a known colchicine derivative and/or a salt thereof wherein: R1, R2, R3, R4, R9, R10, R11 and R12 independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, halogen, C1-4 haloalkyl, nitro, amino, C2-4 acylamino, C1-4 alkyl or dialkylamino, hydroxyl, C1-4 alkoxy, C1-4 alkylthio, a group of the formula &mdashSO2N(Rx)2 or SO2Rx where Rx is C1-4 alkyl, C1-4 acyloxy, or optionally substituted phenyl, optionally substituted phenoxy R7 and R8 independently represent hydrogen, C1-4 alkyl or C1-4 acyl and R5&prime, R5&Prime, R6&prime and R6&Prime independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, halogen, C1-4 haloalkyl, nitro, amino, C2-4 acylamino, hydroxyl, C1-4 alkoxy or C1-4 alkylthio a group of the formula &mdashSO2N(Rx)2 or SO2Rx where Rx is C1-4 alkyl, C1-4 acyloxy, or optionally substituted phenyl.
