Long-acting single-chain insulin analogues

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专利权人:

Case Western Reserve University

发明人:

Weiss, Michael

申请号：

AU2013337250

公开号：

AU2013337250A1

申请日:

2013.11.05

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

A single-chain insulin analogue containing a basic side chain at position A8 (Arginine, Histidine, Lysine, or Ornithine), a basic side chain at position B29 (Arginine, Histidine, Lysine, or Ornithine), and a foreshortened C-domain of length 6-11 residues is provided. Residues C1 and C2 of the C-domain have a net negative charge of -1 or -2 C3 is chosen from a group consisting of Gly, Ala, Pro, or Ser and the remaining C-domain segment is successively derived from the C-domain of IGF-II (RRSR, SRRSR, VSRRSR, RVSRRSR, or SRVSRRSR SEQ ID NO: 13). A method of treating a patient with diabetes mellitus or obesity comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient.

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