PROBLEM TO BE SOLVED: To provide a peptide capable of activating antigen-specific CD8-positive T cells derived from a pathogenic microorganism.SOLUTION: According to the present invention, there are provided: a peptide consisting of 9-50 amino acids that comprises amino acids 61-70 in the amino acid sequence of Ag85B protein of Mycobacterium kansasii a peptide consisting of an amino acid sequence in which one or several amino acids is deleted, substituted or added in the peptide and is capable of activating pluripotent CD8 positive T cells and an acid-fast bacterial peptide vaccine composition comprising a peptide capable of activating CD4 positive T cells against an acid-fast bacterium.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】病原微生物由来抗原特異的CD8陽性T細胞を活性化することができるペプチドの提供。【解決手段】マイコバクテリウム・カンサシイのAg85Bタンパク質のアミノ酸配列において第61~70番目のアミノ酸を含む9~50アミノ酸からなるペプチド、又は、前記ペプチドにおいて1若しくは数個のアミノ酸が欠失、置換若しくは付加されたアミノ酸配列からなり、多能性のCD8陽性T細胞の活性化能を有するペプチド。更に抗酸菌に対するCD4陽性T細胞の活性化能を有するペプチドを含有する抗酸菌症ペプチドワクチン組成物。【選択図】なし
