The present invention relates to methods of administering compositions comprising a progesterone receptor antagonist for use in treating estrogen-dependent conditions. The invention is also directed to methods for treating pain associated with endometriosis. The compositions may be administered to females with endometriosis as well as to females undergoing estrogen and/or selective estrogen receptor modulator (SERM) therapy. In certain embodiments, the invention provides a method for suppressing endometrial proliferation.本發明係關於投予包括黃體酮受體拮抗劑之組合物的方法,用以治療雌激素-依賴性病症。本發明亦針對治療與子宮內膜異位症(endometriosis)有關之疼痛的方法。可將該組合物投予患有子宮內膜異位症之雌性,以及接受雌激素及/或選擇性雌激素受體調節劑(selective estrogen receptor modulator,SERM)療法的雌性。在某些具體事實中,本發明提供壓抑子宮內膜增殖的方法。