A device for the intermittent occlusion of a blood vessel, in particular a vein draining the organ system, comprising an occlusion device which is activatable for intermittent occlusion and positionable in the blood vessel, at least one sensor for the continuous or periodical detection of at least one physiological measurement, and a control device to which the at least one physiological measurement is fed and which cooperates with the occlusion device to control the intermittent occlusion of the blood vessel as a function of said measurement.