Stabilization of liquid solutions of recombinant protein for frozen storage

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专利权人:

Bayer HealthCare LLC

发明人:

Joshi, Omkar,Wang, Deqian,Desponds, Arnaud,Wu, Paul,Tsvetkova, Nelly

申请号：

AU2008245821

公开号：

AU2008245821B2

申请日:

2008.04.22

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

The invention relates to a method for stabilizing a bulk solution of recombinant protein for frozen storage, which comprises providing a partially-purified solution of recombinant protein which has a monovalent salt concentration of at least 100 mM, and adding a carbohydrate to said solution in an amount sufficient that, upon freezing, the solution has a glass transition temperature of -56 °C or higher.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/