15- 15 Composition for inhibiting 15-hydroxyprostaglandin dehydrogenase15-PGDH comprising plant extract

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专利权人:

CHOSUN UNIVERSITY;조선대학교산학협력단;INDUSTRY-ACADEMIC COOPERATION FOUNDATION;INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY

发明人:

CHOI, CHEOL HEE,최철희,CHO, HOON,조훈,SANDEEP KARNA,샌? 카나,MOON, YOUNG SOOK,문영숙,KIM, KWEON CHEON,김권천,CHOI, EUN SEO,최은서

申请号：

KR1020110135340

公开号：

KR1020130068307A

申请日:

2011.12.15

申请国别(地区):

KR

年份:

2013

代理人:

摘要：

PURPOSE: A composition containing a plant extract for suppressing 15-hydroxyprostaglandin dehydrogenase(15-PGDH) is provided to effectively suppress 15-PGDH which is a core material for inactivation of PGE2 with low cytotoxicity. CONSTITUTION: A composition for preventing or treating alopecia contains one or more plant extracts selected from the group consisting of Glochidion hirsulta, Glochidion velutinum, Cinnamomum tetragonum, Memecylon edule, Artocarpus hetrophyllus, Allospondias lakonensis, Commersonia batramia, Syzygium bullockii aff., Syzygium formosum, Choerospondias axillaris, Lumnitzera racemosa, Osbeckia stellata, Trema orientalis, Lithocarpus gymnocarpus, Planchonella obovata, Triumfetta grandidens, Triumfetta bartramia, Mallotus apelta, Baccaurea ramiflora, and Sonneratia alba. The composition is manufactured in the form of a tablet, a pill, a powder, a granule, a capsule, a troch, or a drink. The composition is a parenteral formulation such as an external use formulation or a sterile injection solvent. [Reference numerals] (AA) Example 2； (BB) Example 4； (CC) Example 6； (DD) Example 7； (EE) Example 8； (FF) Example 9； (GG) Example 10본 발명은 식물 추출물을 유효성분으로 함유하는 15-하이드록시프로스타글란딘 탈수소효소(15-PGDH) 억제용 조성물에 관한 것이다. 본 발명의 20종의 식물 추출물들은 PGE2의 비활성화에 핵심물질인 15-PGDH를 매우 우수하게 억제하고, 세포 독성이 적어, 15-PGDH로부터 유발되는 탈모 등의 두피 질환, 소화성 궤양, 구내염 또는 구강궤양, 창상 및 화상, 골절 또는 말초혈관질환의 예방 또는 치료에 유용하게 사용될 수 있다.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/