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Compounds And Methods For Modulating Activity Of Calcium Release Channels
专利权人:
Robert Michael Stongin;Jonathan J. Abramson
发明人:
Jonathan J. Abramson,Robert Michael Stongin
申请号:
US13264055
公开号:
US20120101085A1
申请日:
2010.04.15
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present teachings provide compounds of Formulae I and II: and pharmaceutically acceptable salts, hydrates, complexes, esters, and prodrugs thereof, wherein R1, R1′, R2, R2′, R3, R3′, and X are as defined herein. The present teachings also provide methods of making the compounds of formulae I and II, and methods of treating RyR-associated conditions, disorders, and diseases that include administering a therapeutically effective amount of a compound of formula I or II to a subject in need thereof. In addition, the present teachings relate to methods of reducing the open probability of a ryanodine receptor, and methods of reducing Ca2+ release across a ryanodine receptor (e.g., into the cytoplasm of a cell), by contacting a compound of formula I or II with a ryanodine receptor.
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