NUGENT, HELEN MARIE,EDELMAN, ELAZER,DALAL, ANUPAM,BOLLINGER, STEVE,EPPERLY, SCOTT
申请号：
CA2589597
公开号：
CA2589597C
申请日:
2005.12.06
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Disclosed is an implantable material comprising a biocompatible matrix andcells which, when provided to a vascular access structure, can promotefunctionality generally. For example, implantable material of the presentinvention can enhance maturation of an arteriovenous native fistula as well asprolong the fistula in a mature, functional state suitable for dialysis.Additionally, the present invention can promote formation of a functionalarteriovenous graft suitable for dialysis as well as promote formation of afunctional peripheral bypass graft. Implantable material can be configured asa flexible planar form or a flowable composition with shape~retainingproperties suitable for implantation at, adjacent or in the vicinity of ananastomoses or arteriovenous graft. According to the methods disclosed herein,the implantable material is provided to an exterior surface of a blood vessel.Certain embodiments of the flexible planar form define a slot. The materialsand methods of the present invention comprise cells, preferably endothelialcells or cells having an endothelial-like phenotype.
