Suzanne Walker Kahne,Jonathan G. Swoboda,Timothy C. Meredith,Kyungae Lee,Jennifer Campbell
申请号：
US12997429
公开号：
US20120046282A1
申请日:
2009.06.05
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides Wall Teichoic Acid biosynthesis inhibitors such as compound 1835F03 (targocil) and related synthetic analogs. The invention also provides pharmaceutical compositions thereof and methods for treating bacterial infection and the suppression of growth of bacterial cells by administering a Wall Teichoic Acid biosynthesis inhibitor. The invention is particularly useful for the treatment of Methicillin-resistant Staphylococcus aureus (MRSA). The invention further provides procedures for the syntheses of Wall Teichoic Acid biosynthesis inhibitors. The invention also provides methods for the identification of antibacterial therapeutic agents.
