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PHARMACEUTICAL COMPOSITION AND DOSAGE FORM COMPRISING DRONEDARONE, AND PREPARATION METHOD THEREOF
专利权人:
SANOFI
发明人:
BERNARD ABRAMOVICI,STÉPHANE BEILLES,JEAN-CLAUDE GAUTIER,SANDRA CHAMBONNET
申请号:
PT11796739
公开号:
PT2637645T
申请日:
2011.11.10
申请国别(地区):
PT
年份:
2018
代理人:
摘要:
The disclosure relates to a pharmaceutical composition for oral administration, containing, as active principle, a benzofuran derivative having antiarrhythmic activity, in particular dronedarone and the pharmaceutically acceptable salts thereof, and at least one lipid carrier, said pharmaceutical composition being intended to be used in unit dosage form of the capsule type, in particular with a hard shell. This pharmaceutical composition and the dosage form comprising such a composition aim to limit the meal time effect following oral administration in humans. The lipid carrier allows: the solubilization of the active principle of the invention and the shielding thereof from the negative effects of pH in the intestinal tract, thereby allowing same to be spared from the meal effect to a significant extent.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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