It include being mounted with drug conveying vesicle protein matter or nucleic acid the present invention relates to sour (HA) hydrogel of novel transparent matter. New HA hydrogels provide sustained release preparation that can be used for several clinical and surgery applications, including but not limited to (such as ophthalmology glaucoma, cornea, ocular inflammatory, vitreous-body-retina and medical retinal disease) and dermatological condition.