ULITIN ANDREY BORISOVICH,EVDOKIMOV STANISLAV RUDOLFOVICH,SOLOVIEV VALERIY VLADIMIROVICH,CHERNYH YULIA SERGEEVNA,GONCHAROVA OLGA VLADIMIROVNA,KORZHAVIN DMITRIY VALERIEVICH,CHERNOVSKAYA TATYANA VENIAMIN
申请号：
IN201627027924
公开号：
IN201627027924A
申请日:
2016.08.16
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention relates to the field of medicine and specifically to the field of monoclonal antibodies against human IL 17. More specifically the invention relates to monoclonal antibodies/antagonists of IL 17A which bind with high affinity to an IL 17 epitope wherein the antibodies contain amino acid substitutions in hypervariable regions of heavy and light chains. The antibodies according to this invention can be chimeric humanized or human antibodies or antigen binding fragments thereof and can be used as a medicinal agent for treating autoimmune and inflammatory disorders and disorders of cell proliferation and development. The invention also relates to methods for producing said antibodies.
