A MRSI system (100) includes a structure of interest identifier (206) that identifies a predetermined segmented structure in segmented MRI image data, a positioning rules bank (210) which stores rules for positioning a volume of interest with respect to the identified predetermined segmented structure of the segmented MRI image data, and a volume of interest generator (208) that positions the volume of interest with respect to the identified predetermined segmented structure based on one or more of the rules for positioning the volume of interest with respect to the identified predetermined segmented structure and generates a signal indicative thereof, wherein the signal is analyzed to determine a biochemical composition of a predetermined region of the structure of interest.
