Meis, Judith,Person, Anthony,Chin, Cynthia,Jendrisak, Jerome,Dahl, Gary
申请号：
AU2017251767
公开号：
AU2017251767A1
申请日:
2017.10.25
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
#$%^&*AU2017251767A120171116.pdf#####ABSTRACT The present invention relates to compositions, kits and methods for making and using RNA compositions comprising in vitro-synthesized ssRNA inducing a biological or biochemical effect in a mammalian cell or organism into which the RNA composition is 5 repeatedly or continuously introduced. In certain embodiments, the invention provides compositions and methods for changing the state of differentiation or phenotype of a human or other vertebrate cell. For example, the present invention provides mRNA and methods for reprogramming cells that exhibit a first differentiated state or phenotype to cells that exhibit a second differentiated state or phenotype, such as to reprogram human somatic cells to 0 pluripotent stem cells.
