DE JUAN JR,DE JUAN, JR., EUGENE,BOYD STEPHEN,BOYD, STEPHEN,REICH CARY,REICH, CARY,RAPACKI ALAN,RAPACKI, ALAN,GIFFORD HANSON,GIFFORD, HANSON, S.,DEEM MARK,DEEM, MARK
申请号：
ES07759961
公开号：
ES2640458T3
申请日:
2007.04.02
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A system drug delivery comprising a modular system that includes an insert (1010) drug core and a stopper (1020) of silicone tip which accommodates the insert drug core, the insert (1010) being adapted drug core that is placed in the hole (1022) cap (1020) tip and held in place by an interference fit between the outer diameter of the insert (1010) drug core and the inside diameter of the hole the silicon plug the insert (1010) drug core comprising a drug coating (1014) which houses a drug core and fits snugly against the drug core It is made the coating from a material which is substantially impermeable to a therapeutic agent so that the rate of migration of the therapeutic agent can be controlled largely by the exposed surface area of the drug core is not covered by the body of the coating silicone, acrylates, polyethylenes, polyurethane: the drug core therapeutic agent and materials to provide sustained release of the therapeutic agent, wherein the core (1012) of drug comprises a core of non-biodegradable drug selected from the group consisting comprising , hydrogel, polyester, polypropylene, polytetrafluoroethylene (PTFE), expanded PTFE (ePTFE), polyether ether ketone (PEEK), nylon, extruded collagen, polymer foam, silicone rubber, polyethylene terephthalate, polyethylene, polycarbonate urethane and polyimide, and wherein one end of the insert (1010) drug core is exposed to contact with tear fluid or tear film to allow diffusion of the drug in the tear of the eye and wherein a film of cyanoacrylate is applied to the end of the insert (1010) core opposite the end exposed drug.Un sistema de suministro de fármacos que comprende un sistema modular que incluye un inserto (1010) de núcleo de fármaco y un tapón (1020) de punta de silicona que puede alojar el inserto de núcleo de fármaco, estando adaptado el inserto (1010) de núcleo de fármaco para que se coloque en el orificio (1022) del tapón (1020) de punta y se mantenga en su sitio mediante un ajuste de interferen
