HAMILTON, NIALL MORTON,GROVE, SIMON JAMES ANTHONY,KICZUN, MICHAEL JOHN,MORPHY, JOHN RICHARD,SHERBORNE, BRAD,LITTLEWOOD, PETER THOMAS ALBERT,BROWN, ANGUS RICHARD,KINGSBURY, CELIA,OHLMEYER, MICHAEL,HO,
申请号：
CA2631816
公开号：
CA2631816C
申请日:
2006.12.18
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The invention provides for compounds having the structure according to theformula I wherein: X is a carbon or nitrogen atom； Ar is phenyl orheteroaromatic ring； R1 is hydrogen, halogen, CN or (1 C-4C)alkyl； R2 ishydrogen, halogen or optionally fluorinated (1 C-3C)alkoxy； R3 and R5 areindependently hydrogen, optionally halogenated (1C- 4C)alkyl, optionallyhalogenated (1 C-4C)alkoxy, optionally halogenated aryl(1C-4C)alkoxy,optionally halogenated (1 C-4C)alkenyl or hydroxylmethyl； R4 is hydrogen,halogen, optionally halogenated (1 C-4C)alkoxy or optionally halogenatedaryl(1 C-4C)alkoxy； R6 is hydrogen, benzyl, optionally substituted with one ormore halogens or (1 C-4C)alkyl, or R6 is optionally halogenated (1 C-4C)alkyl；each R7 independently is hydrogen, halogen, optionally halogenated (1 C-4C)alkyl or optionally halogenated (1 C-4C)alkoxy and pharmaceuticallysuitable acid addition salts thereof for use as glucocorticoid receptormodulators, in particular for treatment of central nervous system disorders.
