A controlled release pharmaceutical composition is disclosed, which comprises: a drug core comprising 10-50 mg of Carvedilol or a pharmaceutical acceptable salt thereof, and a first pharmaceutical acceptable polymer, wherein a content of the first pharmaceutical acceptable polymer is 0.01-50% based on a total weight of the drug core； and a controlled release coating layer covering the drug core and comprising a second pharmaceutical acceptable polymer. In addition, a method for manufacturing the aforementioned controlled release pharmaceutical composition is also disclosed.
