Eric Charles Reynolds;Ching Seng Ang;Paul David Veith;Stuart Geoffrey Dashper
发明人:
Stuart Geoffrey Dashper,Ching Seng Ang,Paul David Veith,Eric Charles Reynolds
申请号：
US13547556
公开号：
US20130236488A1
申请日:
2012.07.12
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention is directed to vaccine compositions and methods based on P. gingivalis proteins identified to be regulated by haem availability that can be used in the prevention and treatment of periodontal disease. In particular, two specific internalin-like P. gingivalis proteins, namely PG0350 and PG1374 involved in the internalization of P. gingivalis by host cells, the hypothetical protein, PG1019 purported to be a cell surface lipoprotein and the alkyl hydroperoxide reductase protein, PG0618 have been identified as useful targets for the prevention and treatment of periodontal disease.
