Erik Mogalian,Robert William Scott,Bing Shi,Fang Wang
申请号：
US14600911
公开号：
US09139570B2
申请日:
2015.01.20
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Amorphous and crystalline solid forms of the anti-HCV compound (1-{3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester (Compound I) were prepared and characterized in the solid state:Also provided are processes of manufacture and methods of using the amorphous and crystalline forms.
