Lopez, John,Draper, Peter,Vashishtha, Sankalp,Klassen, Nancy,Armstrong, Christina
申请号：
AU2011207061
公开号：
AU2011207061A1
申请日:
2011.01.19
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
An NSAID formulation for encapsulation into a soft gel capsule with increased stability, concentration and bioavailability of the NSAID. The preferred NSAIDS are naproxen, ibuprofen, indomethacin and diclofenac, which are provided in both an acidic and basic form in the fill formulation. The pH values of fill formulations may be adjusted without additional process steps. A process for increasing the achievable concentration of an active NSAID pharmaceutical ingredient in a fill composition for dosage units is also provided. The highly concentrated NSAID formulation permits a reduction in the fill volume or dosage unit size, or an increase in concentration of the NSAID in each dosage unit.
