PROBLEM TO BE SOLVED: To develop a PDE5 activity inhibitor that can be effectively utilized for prevention and improvement of ED, has no side effect, and is derived from natural products, and provide a composition in an industrially practical manner.SOLUTION: The present invention provides a PDE5 activity inhibitor that contains an extract or purified product obtained by extracting from an Astilbe plant, such as Astilbe thunbergii(SIEB. et ZUCC).MIQ. using water and/or hydrophilic organic solvent, and further provides an oral composition such as food and drink containing the PDE5 activity inhibitor.SELECTED DRAWING: NoneCOPYRIGHT: (C)2019,JPO&INPIT【課題】 EDの予防や改善に有効利用し得る副作用のない天然物由来のPDE5活性阻害剤を開発し、これを産業上有用に活用できる態様の組成物として提供する。【解決手段】 アカショウマ等のチダケサシ属に属する植物を水及び/又は親水性有機溶剤を用いて抽出したエキス又は精製物を含有するPDE5活性阻害剤、更にはこのPDE5活性阻害剤を含有する飲食品等の経口組成物。【選択図】なし
