Apparatus and methods for delivering medicament to a patient. The apparatus may include elements with different capacities to attenuate or absorb sterilizing radiation. The apparatus may include a medicament delivery assembly with interactive elements for dose-setting, priming and medicament ejection. The assembly may include a chamber housing a radiation-sensitive medicament present in the apparatus during sterilization by electron beam. The assembly may include an actuator chassis, a drive mechanism, a needle-priming mechanism and a fluid-displacement mechanism including a fluid-displacement member. The chassis may be fixed, relative to an outlet, to the chamber. The member may be slidingly and/or threadingly engaged with the chassis, and may be configured to move relative to the outlet to deliver the medicament through the outlet. Assembly elements may be nested coaxially and/or stacked axially. The assembly may include at least one hollow region. The hollow region may reduce beam attenuation or reduce radiation absorption.本發明係關於用於將藥劑遞送至一患者之設備及方法。該設備可包括具有衰減或吸收滅菌輻射之不同能力的元件。該設備可包括具有用於劑量設定、注液及藥劑射出之交互式元件的一藥劑遞送總成。該總成可包括一腔室，該腔室容納在藉由電子射束滅菌期間存在於該設備中之一輻射敏感藥劑。該總成可包括一致動器底盤、一驅動機構、一針注液機構及一流體置換機構，該流體置換機構包括一流體置換構件。該底盤可相對於一出口固定至該腔室。該構件可與該底盤滑動地及/或螺紋地接合，且可經組態以相對於該出口移動以經由該出口遞送該藥劑。總成元件可同軸地嵌套及/或軸向地堆疊。該總成可包括至少一個空心區。該空心區可減少射束衰減或減少輻射吸收。
