A balloon structure includes a proximal balloon portion having a first internal volume, a distal balloon portion having a second internal volume, and a central balloon portion disposed between and joined with the proximal and distal balloon portions. The central balloon portion has a third internal volume isolated from the first and second internal volumes. A first lumen is associated with the third internal volume to direct pressure to the third internal volume for inflation of the central balloon portion. At least one second lumen is associated with the first and second internal volumes to direct pressure to the first and second internal volumes for inflation of the proximal balloon portion and the distal balloon portion. Whereby, upon inflation, the central balloon portion dilates, or delivers other treatments to tissue in the passage, with the proximal and distal balloon portions limiting movement of the balloon structure in the passage.
