entecavir microsphere, method for preparation of an entecavir microsphere, and pharmaceutical composition

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专利权人:

DONG KOOK PHARM. CO.; LTD

发明人:

DEOK KEUN LEE,KYUNG HOI CHA,SHIN EOM

申请号：

BR112016002342

公开号：

BR112016002342A8

申请日:

2013.08.06

申请国别(地区):

BR

年份:

2018

代理人:

摘要：

1/1 summary "entecavir microsphere and composition" The present invention relates to entecavir microspheres and a pharmaceutical composition for parenteral administration containing the same. entecavir microspheres are manufactured by a method comprising the steps of: dissolving entecavir and a biodegradable biocompatible polymer in at least one solvent； placing the entecavir and biodegradable biocompatible polymer solution in a hydrophilic polymer solution followed by stirring to form microspheres； and remove the solvent. entecavir is sufficiently sealed in the entecavir microsphere by approximately 80% or more based on the amount of input, and entecavir elution is maintained for 30 days or more, so entecavir microspheres may continuously exhibit effectiveness, thereby improving patient compliance with medication.1 / 1 resumo “microesfera entecavir, e, composiã‡ãƒo fa rma cãš u t ica â€� a presente invenã§ã£o se refere a microesferas entecavir e uma composiã§ã£o farmacãªutica para administraã§ã£o parental contendo a mesma. as microesferas entecavir sã£o fabricadas por um mã©todo compreendendo as etapas de: dissolver entecavir e um polã­mero biocompatã­vel biodegradã¡vel em pelo menos um solvente； colocar a soluã§ã£o de entecavir e polã­mero biocompatã­vel biodegradã¡vel em uma soluã§ã£o de polã­mero hidrofã­lico, seguida de agitaã§ã£o, para formar microesferas； e remover o solvente. a entecavir ã© suficientemente vedada na microesfera entecavir em aproximadamente 80% ou mais com base na quantidade de entrada, e a eluiã§ã£o da entecavir ã© mantida por 30 dias ou mais, e entã£o as microesferas entecavir podem continuamente exibir eficã¡cia, assim, melhorando a observã¢ncia da medicaã§ã£o dos pacientes.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/