8-karbamoil-2-(2,3-disubstituiran pirid-6-il)-1,2,3,4-tetrahidroizokinolinski derivati kot apoptozo inducirajoča sredstva za zdravljenje raka ter imunskih in avtoimunskih bolezni
WANG Le,DOHERTY George,WANG Xilu,TAO Zhi-Fu,BRUNKO Milan,KUNZER Aaron R.,WENDT Michael D.,SONG Xiaohong,FREY Robin,HANSEN Todd M.,SULLIVAN Gerard M.,JUDD Andrew,SOUERS Andrew,SONG X
申请号：
SI201230730
公开号：
SI2766361T1
申请日:
2012.10.11
申请国别(地区):
SI
年份:
2016
代理人:
摘要：
Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl； Y1 is phenylene or heteroarylene； L1 is a linker； Y2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl； Z1 is C(0)OR9, C(O)NR10R11, C(0)R11, NR10C(O)R11, etc.
