Devices and systems for providing retroperfusion and autoretroperfusion therapies to a brain. In certain embodiments, the devices and systems disclosed herein comprise a flow unit configured to adjust the flow rate and pressure of the arterial blood used for perfusion of the venous system. Methods for delivering a bridge retroperfusion therapy are also disclosed such that, after the onset of a stroke or other adverse cerebral event, the brain cells window of viability may be extended and other treatments, including pharmaceutical and neuroprotective therapies, may be more effectively utilized.
