Bradley J. Heidrich,Jennifer F. Nemeth,Walter K. Nishioka, Jr.,Thai Dinh,Rosa Maria Fernandes Cardoso,Darlene Pizutti,Brandy Strake,Jamie Fisher,Ricardo Marcos Attar,Francois Gaudet,Mark E. Salvati
申请号：
US15340149
公开号：
US20170121420A1
申请日:
2016.11.01
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Provided herein are antibodies that specifically bind to IL1RAP. Also described are related polynucleotides capable of encoding the provided IL1RAP-specific antibodies or antigen-binding fragments, cells expressing the provided antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled antibodies or antigen-binding fragments. In addition, methods of using the provided antibodies are described. For example, the provided antibodies may be used to diagnose, treat, or monitor IL1RAP-expressing cancer progression, regression, or stability to determine whether or not a patient should be treated for cancer or to determine whether or not a subject is afflicted with IL1RAP-expressing cancer and thus may be amenable to treatment with an IL1RAP-specific anti-cancer therapeutic, such as the multispecific antibodies against IL1RAP and CD3 described herein.
