Imaging compounds for tracking histone deacetylase inhibitor and synthesis method thereof

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专利权人:

Ming-Hsin Li

发明人:

Ming-Hsin Li

申请号：

US14315318

公开号：

US20150374859A1

申请日:

2014.06.25

申请国别(地区):

US

年份:

2015

代理人:

摘要：

A synthesis method of labeling histone deacetylase inhibitor (HDAC inhibitors) SC027 with Gallium-67 or Gallium-68 radionuclide, wherein a labeled precursor DOTA-SC027 which comprises DOTA-NHS-ester (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-N-hydroxysuccinimide-ester) and HDACi-SC027 is prepared for the synthesis to label HDACi-SC027 with Gallium-67 or Gallium-68 radionuclide for producing imaging tracers for tracking the HDACi.

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