INSERM (Institut National de la Santé et de la Recherche Médicale);Universite de Nantes
发明人:
申请号：
EP15715708.2
公开号：
EP3126374B1
申请日:
2015.04.01
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The invention relates to an peptide derived from a polymorphic region of donor MHC class II molecules which induces tolerance and thus prevents transplant rejection in a patient in need thereof. The invention relates to isolated peptide of length ranging between 11 and 16 amino acids compriings the amino acid sequence: SDVGEYR (SEQ ID NO: 1) or a function-conservative variant thereof for use as drug. The invention relates to anmethod for determining whether a transplanted patient is tolerant, comprising a step of determining the presence of CD8CD45RCTregs in a biological sample obtained from said transplanted patient, wherein the presence of CD8CD45RCTregs is indicative of tolerance.
