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Compositions and methods containing alkylglycosides for stabilizing protein-containing formulations
专利权人:
GENENTECH INC.
发明人:
ESUE OSIGWE,SHARMA VIKAS K.
申请号:
NZ60514711
公开号:
NZ605147A
申请日:
2011.06.23
申请国别(地区):
NZ
年份:
2014
代理人:
摘要:
Disclosed is an aqueous composition of matter comprising an antibody and an alkylglycoside having a critical micelle concentration (CMC) value of about 1.0 mM or greater in water at 25 degrees Celsius, wherein the alkylglycoside is present at a concentration that is lower than the CMC value of the alkylglycoside in water at 25 degrees Celsius. Also disclosed is a method of inhibiting agitation-induced aggregation of an antibody present in an first aqueous solution, said method comprising the step of adding to said first aqueous solution an agitation-induced aggregation inhibiting amount of an alkylglycoside having a CMC value of about 1.0 mM or greater in water at 25 degrees Celsius, wherein the alkylglycoside is added to a final concentration that is lower than the CMC value of the alkylglycoside in water at 25 degrees C, thereby providing a second aqueous solution.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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