A composition comprising the compounds isolated from the Inulae Flos extract of Inula japonica Thunberg having anti-inflammatory or anti-allergic activity
PURPOSE: A composition containing compounds isolated from Inula japonica extract for preventing or treating allergic diseases is provided to suppress prostaglandin and leukotriene generation. CONSTITUTION: A pharmaceutical composition for preventing and treating inflammatory or allergic diseases contains tomantosin, britanin, or quercetagetin 3,4'-dimethyl ether as an active ingredient, isolated from Inula japonica extract. The Inula japonica extract is a polar solvent soluble extract or non-polar solvent soluble extract. The polar solvent soluble extract is prepared using water, methanol, ethanol, butanol, or mixture solvent thereof. The non-polar solvent soluble extract compound is prepared by isolating with hexane, chloroform, methylene chloride, or ethyl acetate. A health food for preventing and treating inflammatory and allergic diseases contains tomantosin, britanin, or quercetagetin 3,4'-dimethyl ether as an active ingredient. The health food is powder, granule, tablet, capsule, or beverage.본 발명은 선복화 추출물로부터 분리된 화합물을 유효성분으로 함유하는 염증 및 천식과 같은 알러지 질환의 예방 또는 치료용 조성물에 관한 것으로, 상기 화합물이 각종 염증 및 알러지 질환의 원인이 되는 비만세포로부터 시클로옥시게나제-2 (COX-2) 의존적 프로스타글란딘 (prostaglandin) 생성 및 류코트리엔 (leukotriene)의 생성을 억제함과 동시에 비만세포로부터 히스타민 (histamine)의 방출을 억제하므로, 각종 염증 또는 알러지 질환의 예방 및 치료를 위한 의약품 또는 건강기능식품으로 유용하게 이용될 수 있다.
