A jaw assembly for vessel sealing device having a pair of jaw member that are pivotally coupled together via two flanges associated with one of the jaw members and a single, centrally positioned flange associated with the other of the jaw members. The flanges include cam slots so that axial movement of a drive shaft can open and close the jaw members. The jaw members may include a knife pathway for axial movement of a knife blade that is positioned to one side of the central flange and thus offset from the central axis of the jaws.