President and Fellows of Harvard College;Massachusetts Institute of Technology;Dana-Farber Cancer Institute, Inc.
发明人:
Ellis L. Reinherz,Kyoung Joon Oh,Mikyung Kim,Gerhard Wagner,Zhen-Yu J Sun,Darrell J. Irvine,Anna Bershteyn
申请号：
US16683882
公开号：
US20200188475A1
申请日:
2019.11.14
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure relates to reagents (antigenic and/or immunogenic reagents) and kits that are useful in a variety of in vitro, in vivo, and ex vivo methods including, e.g., methods for inducing an immune response, or for generating an antibody, in a subject. The reagents described herein can be used in the treatment or prevention of HIV-1 infections. In addition, the disclosure provides methods and compositions useful for designing (or identifying) an agent that binds to an membrane proximal external region (MPER) of an HIV-1 gp160 polypeptide or an agent that inhibits the fusion of an HIV-1 particle to a cell.
