Augen A. Pioszak;Huaqiang Eric Xu;Thomas J. Gardella
发明人:
Huaqiang Eric Xu,Augen A. Pioszak,Thomas J. Gardella
申请号：
US13260699
公开号：
US08563513B2
申请日:
2010.03.26
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Provided herein are Parathyroid hormone (PTH) peptides and parathyroid hormone-related protein (PTHrP) peptides (e.g., PTH analogs, PTHrP analogs), and related variants, chemical derivatives, fusion polypeptides, multimeric polypeptides, and peptidomimetics, peptoids, the like. Also provided are their use in methods for activating the PTH receptor in a cell (e.g., an osteoblast), methods of treating a subject with bone loss (e.g., by administration of a PTH peptide or PTHrP peptide (e.g., a PTH analog or PTHrP analog)), methods of ameliorating a symptom associated with osteoporosis in a subject, methods of retarding the progression of osteoporosis in a subject, and methods of regenerating bone in a subject.
