UTILISATION DE PEPTIDES AROMATIQUES CATIONIQUES POUR LE TRAITEMENT DE LA MALADIE DE NIEMANN-PICK CHARACTERISÉE PAR UN DYSFONCTIONNEMENT MITOCHONDRIAL INDUIT PAR LE CHOLESTÉROL
The present disclosure provides aromatic-cationic peptide compositions and methods of using the same. The methods comprise use of the peptides in inhibiting cholesterol-induced cytochrome c peroxidase activity, promoting reduction of cytochrome c, and inhibition of cardiolipin peroxidation to treat, prevent or ameliorate cholesterol-induced mitochondrial dysfunction.