Sung Wuk Kim,Sung Soo Jun,Hyae Gyeong Cheon,Kwang Rok Kim,Sang Dal Rhee,Won Hoon Jung,Jong Cheol Lee
申请号：
US13123417
公开号：
US08642647B2
申请日:
2009.10.13
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides an N1-benzo[1,3]dioxol-5-ylmethyl-N2-substituted biguanide derivative of formula (I) or a pharmaceutically acceptable salt thereof, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient. The inventive N1-benzo[1,3]dioxol-5-ylmethyl-N2-substituted biguanide derivative exhibits improved blood glucose level- and lipid level-lowering effects even with a reduced dosage as compared to conventional drugs, and thus, it is useful for preventing or treating diabetes, metabolic syndromes such as insulin-independent diabetes, obesity and atherosclerosis, or a P53 gene defect-related cancer.
