Compounds having the formula I are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating adenoma, bladder cancer, brain cancer, breast cancer, colon cancer, epidermal carcinoma, follicular carcinoma, cancer of the genitourinary tract, glioblastoma, Hodgkin's disease, head and neck cancers, hepatoma, keratoacanthoma, kidney cancer, large cell carcinoma, leukemias, lung adenocarcinoma, lung cancer, lymphoid disorders, melanoma and non-melanoma skin cancer, myelodysplasia syndrome, neuroblastoma, non-Hodgkins lymphoma, ovarian cancer, papillary carcinoma, pancreatic cancer, prostate cancer, rectal cancer, sarcoma, small cell carcinoma, testicular cancer, tetracarcinomas, thyroid cancer, and undifferentiated carcinoma.Los Compuestos que tienen fórmula I son inhibidores de la cinasa ERK. También se describen composiciones y métodos para trataradenoma, cáncer de vejiga, cáncer cerebral, cáncer de mama, cáncer de colon, carcinoma epidérmico, carcinoma folicular, cáncer del tracto genitourinario, glioblastoma, enfermedad de Hodgkin, cánceres de cabeza y cuello, hepatoma, queratoacantoma, cáncer de riñón, carcinoma de células grandes, leucemias, adenocarcinoma de pulmón, cáncer de pulmón, transtornos linfoides, cáncer de piel melanoma y no melanoma, síndrome mielodisplástico, neuroblastoma, linfoma no Hodkin, cáncer de ovario, carcinoma papilar, cáncer pancreático, cáncer de próstata, cáncer rectal, sarcoma, carcinoma de células pequeñas, cáncer testicular, tetracarcinomas, cáncer de toriodes y carcinoma indiferenciado (ver Fórmula).
