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TRANSDERMAL DELIVERY SYSTEM FOR THE ADMINISTRATION OF ROTIGOTINE
专利权人:
Dietrich Wilhelm Schacht
发明人:
Dietrich Wilhelm Schacht,Mike Hannay,Hans-Michael Wolff
申请号:
US13457848
公开号:
US20120215185A1
申请日:
2012.04.27
申请国别(地区):
US
年份:
2012
代理人:
摘要:
An improved Transdermal Delivery System (TDS) comprising a backing layer inert to the components of the matrix, a self-adhesive matrix containing rotigotine and a protective foil or sheet to be removed prior to use,characterized in thatthe self-adhesive matrix consists of a solid or semi-solid semi-permeable polymer(1) wherein rotigotine in its free base form has been incorporated,(2) which is saturated with rotigotine and contains said rotigotine as a multitude of microreservoirs within the matrix,(3) which is highly permeable for the free base of rotigotine,(4) which is impermeable for the protonated form of rotigotine,(5) wherein the maximum diameter of the microreservoirs is less than the thickness of the matrix.is provided. Said TDS provides for enhanced flux of rotigotine across the TDS/skin interface.
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