LAI, JIANN SHIUN,赖建勳,賴建勳,LAI, YAN DA,赖彦达,賴彥達,WU, YEN YU,吴彦宥,吳彥宥,TSAI, YI JIUE,蔡宜珏,蔡宜玨,LIN, YU YING,林佑莹,林祐瑩
申请号：
TW103146069
公开号：
TW201524998A
申请日:
2014.12.29
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
An anti-VEGF antibody, or a binding fragment thereof, which includes a heavy-chain variable region that comprises: (1) a CDRH1 sequence selected from SEQ ID NO: 17, 20, 23, 26, 29, 32, 35, or 38), (2) a CDRH2 sequence selected from SEQ ID NO: 18, 21, 24, 27, 30, 33, 36, or 39, and (3) a CDRH3 sequence selected from SEQ ID NO: 19, 22, 25, 28, 31, 34, 37, or 40 and a light-chain variable region that comprises: (1) a CDRL1 sequence selected from SEQ ID NO: 41, 44, 47, 50, 53, 56, 59, or 62, (2) a CDRL2 sequence selected from SEQ ID NO: 42, 45, 48, 51, 54, 57, 60, or 63, and (3) a CDRL3 sequence selected from SEQ ID NO: 43, 46, 49, 52, 55, 58, 61, or 64. A method for treating or preventing a VEGF-related disorder, e.g., diabetic retinopathy, age-related macular degeneration, or cancer, which uses the antibodies.一種抗血管內皮生長因子(VEGF)抗體或其結合片段,其包括一重鏈可變區,包含:(1)一CDRH1之序列,選自SEQ ID NO:17、20、23、26、29、32、35或38;(2)一CDRH2之序列,選自SEQ ID NO:18、21、24、27、30、33、36或39;及(3)一CDRH3之序列,選自SEQ ID NO:19、22、25、28、31、34、37或40;以及一輕鏈可變區,包含:(1)一CDRL1之序列,選自SEQ ID NO:41、44、47、50、53、56、59或62;(2)一CDRL2之序列,選自SEQ ID NO:42、45、48、51、54、57、60或63;及(3)一CDRL3之序列,選自SEQ ID NO:43、46、49、52、55、58、61或64。一種用於治療或預防血管內皮生長因子相關疾病(如糖尿病性視網膜病、老年性黃斑部病變或癌症)的方法,其係使用該抗體。
