THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人:
UNCITI-BROCETA, Asier,FRASER, Craig,O. CARRAGHER, Neil
申请号：
GBGB2016/051057
公开号：
WO2016/185160A1
申请日:
2016.04.15
申请国别(地区):
WO
年份:
2016
代理人:
摘要：
A first aspect of the- invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, (Formula (I)) wherein: R1 is (CH2)mNR11R12R2 is selected from H, halo, OR13, ΝΗR13, alkyl, alkenyl and alkynyl R3 is selected from alkyl, alkenyl, alkynyl, aryl, halo, aryloxy, NHCO2R4, NHCONR5R6, NHCOR7, NH-alkyl, NH-alkenyl, NH(CH2)n-aryl, (CH2)p-heteroaryl, (CH2)qCO2R8, (CH2)rCOR9 and NHSO2R10, wherein each alkyl, alkenyl, aryl or heteroaryl moiety in the aforementioned list is optionally further substituted by one or more groups selected from alkyl, halo OH, NH2, alkoxy, aryloxy, alkylamino, arylamino, carboxyl and carboxamide R4 to R10 and R13 are each independently selected from alkyl, alkenyl and aryl R11 and R12 are each independently selected from alkyl and alkenyl or R11 and R:12 are linked together with the nitrogen to which they are attached to form a heterocycloalkyl or heterocycloalkenyl group n, m, p, q and r are each independently selected from 0, 1, 2,.3. 4, 5 and 6. Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing according to the invention.Un premier aspect de la présente invention concerne un composé de formule (I), ou un sel ou ester pharmaceutiquement acceptable de celui-ci, (formule (I)), dans laquelle : R1 est (CH2)mNR11R12 R2 est choisi parmi H, halogéno, OR13, ΝΗR13, alkyle, alcényle et alcynyle R3 est choisi parmi alkyle, alcényle, alcynyle, aryle, halogéno, aryloxy, NHCO2R4, NHCONR5R6, NHCOR7, NH-alkyle, NH-alcnéyle, NH(CH2)n-aryle, (CH2)p-hétéroaryle, (CH2)qCO2R8, (CH2)rCOR9 et NHSO2R10, chaque fraction dalkyle, dalcényle, daryle ou dhétéroaryle de la liste mentionnée ci-dessus étant facultativement davantage remplacée par un ou plusieurs groupes choisis parmi alkyle, halogéno, OH, NH2, alcoxy, aryloxy, alkylamino, arylamino, carboxyle et carboxamide R4 à R10 et R13 sont choisis chacun indépendamment parmi alkyle, alcényle et aryle R11 et R12 sont choisis chacu
