ZHU, Rui,PEI, Tao,LI, Zhen,KANNER, Steven,WONG, So
申请号：
CL2020000593
公开号：
CL2020000593A1
申请日:
2020.03.09
申请国别(地区):
CL
年份:
2020
代理人:
摘要：
T. Oacute； n refers to the agent of iarn, such as the double Hebrew agent of iarn, which can inhibit the expression of amp； oacute； n is the gene from apolipoproterate and amp； Iacute； Na C-III (tambi amp； eacute； n is called APOC3, apoC-III, apoC-III and apo C-III),There are also works by iarn agents for APOC3 The APOC3 staff of iarn in Aqua amp and Iacute can be merged into the targeted alliance, including n-acetyl-galatosamina, to promote CI amp, oacute, N-C amp, eacute, Lulas, including hep bromine cells. Tambi amp； eacute； n describes the ingredients of pharmacy and amp； eacute； medicinal materials including one or one M amp； Aacute； APOC3 agents of Aacute； iarn can choose one or one of M amp； Aacute； s therapists amp agents； eacute； extra props. Administration and provincial agencies； oacete； n de la expui amp； oacute； n de UN Gen de APOC3,The results may be that the subjects had lower levels of M amp, Aacute, trigic amp, eacute, ridis and / or cholesterol. Iarn preparations for the treatment of APOC3 can be used in M amp； eacute； all preparations for the treatment of APOC3 related diseases and diseases, including hypertension, cardiovascular diseases and other metabolic diseases and diseases.<；p>；La presente divulgació；n se refiere a agentes de iARN, por ejemplo agentes de iARN de doble hebra, capaces de inhibir la expresió；n de genes de apolipoproteí；na C-III (tambié；n denominada APOC3, apoC-III, APOC-III y APO C-III), y a composiciones que incluyen agentes de iARN para APOC3. Los agentes de iARN para APOC3 divulgados aquí； pueden ser conjugados a ligandos de direccionamiento, incluyendo ligandos que incluyen N-acetil-galactosamina, para facilitar la administració；n a cé；lulas, incluyendo a hepatocitos. Tambié；n se describen composiciones farmacé；uticas que incluyen uno o má；s agentes de iARN para APOC3, opcionalmente con uno o má；s agentes terapé；uticos adicionales
