INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION;F. HOFFMANN-LA ROCHE AG
发明人:
DIMARCHI, RICHARD D.,HOFFMANN, EIKE,KOPETZKI, ERHARD,RUETH, MATTHIAS,TIEFENTHALER, GEORG
申请号：
CA2877363
公开号：
CA2877363A1
申请日:
2013.06.18
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Herein is reported an Fc-region fusion polypeptide or Fc-region conjugate comprising one to four incretin receptor ligand polypeptides and a variant human Fc-region with a mutation of the amino acid residue at position 329 and at least one further mutation of at least one amino acid selected from the group comprising amino acid residues at position 228, 233, 234, 235, 236, 237, 297, 318, 320, 322 and 331 to a different residue, wherein the residues in the Fc-region are numbered according to the EU index of Kabat and its use as a medicament.
